July 9 : A team of scientists have designed a virus that is safe to normal tissue but deadly to cancer and the virus has shown promising results in preliminary study.

The virus, called NV1020, is a type of herpes simplex virus modified so that it selectively replicates in virus cells, killing them in the process.

“It doesn’t replicate in normal, healthy cells, so our hope is that it will help fight cancers without causing side-effects in the rest of the body,” said Dr. Axel Mescheder, VP Clinical Research & Development, from the Munich-based biotech company MediGene. The study is conducted in seven leading US-cancer centers, with Dr. Tony Reid from the University of California in San Diego, CA as Principal Investigator Dr. Mescheder’s poster presentation described the case of a patient whose cancer had spread to 10 different places around the liver and four in the lungs. He was given the virus treatment in four weekly infusions direct into blood stream, followed by two cycles of approved chemotherapy.

Six months after treatment, scans showed the liver masses had nearly disappeared.

“The reduction in the tumor masses was really impressive in this patient.. The hepatic masses almost disappeared,” Dr. Mescheder said. The patient survived for 12 months after treatment.

“In the current study, the scientists are testing the treatment in patients with colorectal cancer that have not responded to chemotherapy and where the cancer has spread to the liver. We are hoping to extend overall survival,” Dr. Mescheder said.

So far, the findings are looking positive. The treatment seems very tolerable for patients and safe.

“The results are really quite encouraging at this early stage,” he said.

Almost 40 pct of patients with colorectal cancer ultimately die from metastatic disease, where the cancer spreads to other parts of the body. Most of the spreading occurs to the liver and 15 pct of patients have liver metastases at the time of diagnosis.

The latest human results reported today follow testing in the lab and in animals where the virus was shown to be effective at killing colorectal cancer cells and liver cancers. (ANI)